Another finding of this study is that besides weight loss, IQP-AE-103 showed beneficial effects on lipid metabolism. A significantly higher proportion of subjects in the high-dose IQP-AE-103 group experienced a reduction in triglyceride levels at the end of the study compared with placebo. In subjects with higher baseline total cholesterol levels (>6.2 mmol/L), high dose of IQP-AE-103 was shown to significantly reduce total cholesterol and LDL-cholesterol (pre-post change). Therefore, current outcome suggests that long-term treatment with IQP-AE-103 could be beneficial for subjects with elevated blood lipid levels in reducing the risk of cardiovascular disease.

Hunger Buddy does not contain any ingredient of animal origin and has no added artificial, flavourings, salt or preservatives. Figure 2: Litramine 14-week placebo-controlled, randomised, double-blind clinical trial results Weight loss through digestive enzyme inhibition Once you did so, you can choose a preset to change and adjust the quality of your PDF file. You can choose between "basic" and "strong" compression, and using a preset. Safety evaluation included measurement of laboratory parameters (full blood count, clinical chemistry, liver and renal functions and fat-soluble vitamins (A, D, E, and K) levels) and urine analysis at visit 1 and visit 6, as well as assessment of vital signs during each visit. Adverse events were recorded, regardless of causality at every visit. Global evaluation of tolerability by subjects and investigators was performed at the end of the study. In the next step, the weight loss and weight maintenance efficacy of IQP-AE-103 should be evaluated in longer clinical trials. Also, it would be worthwhile to further investigate any positive effect on cardiovascular risk factors associated with obesity, particularly in subjects with elevated blood lipids. For further elucidation of mode of action, an assessment of fecal fat excretion, or postprandial blood lipid changes and potentially gut microbiome study could be considered. 5. Conclusion and Implication

Common Uses

The primary endpoint of this study was the comparison of the mean body weight (kg) change between IQP-AE-103 high dose and placebo after 12 weeks of intervention from baseline, in overweight and moderately obese subjects. The evaluation of the efficacy of IQP-AE-103 was based on the null hypothesis that there are no statistical differences between IQP-AE-103 and placebo in mean reduction of body weight after 12 weeks of treatment. The nonparametric Mann–Whitney U test for independent samples was applied. The testing was carried out by the determination of the rank sum of individual body weight changes.

The animal and in vitro data used to support the findings of this study are currently under embargo, whereas the research findings are commercialized. Data requests will be considered by the corresponding author 12 months after publication of this article. Conflicts of Interest XLS-Medical For the treatment and prevention of excess weight. Fight food cravings & cut portion sizes. 94% experinced a feeling of fullness. For you, we are running many services free of cost. Those services are expensive to run, requiring multiple servers to process and encode the files. Blood lipid parameters, fasted glucose, and hemoglobin A1c (HbA1c) were assessed at visit 1 and visit 6.

Responder rate for subjects who lost ≥3% and ≥5% of initial body weight at v6. LD = low dose; HD = high dose. a vs. placebo; b vs. placebo; c vs. low-dose group. Based on the physicochemical properties of okra pods and inulin, and the fat binding capacity shown in vitro, it was hypothesized that a product containing powdered okra pods and inulin could potentially contribute to weight loss. Hence, the primary objective of this randomised, double-blind, placebo-controlled clinical study was to evaluate the weight loss potential of IQP-AE-103 over the period of 12 weeks in overweight and moderately obese subjects. In this study, it was demonstrated that in conjunction with a hypocaloric diet, IQP-AE-103 at both low dose (990 mg okra and 255 mg inulin/day) and high dose (1980 mg okra and 510 mg inulin/day) causes significant weight loss and that the effects are greater than those in the placebo. Baseline body weight was reduced by 5.03 ± 2.50 kg in the high-dose group and by 3.01 ± 2.19 kg in the low-dose group, compared with 0.98 ± 2.06 kg in the placebo group. Also, for the high-dose group, weight loss effect due to IQP-AE-103 consumption was observed as early as at 2 weeks of treatment and was sustained over the course of the 12-week intake period. More importantly, the proportion of subjects who lost at least 5% of baseline body weight was 60.0% in the high-dose IQP-AE-103 group, a proportion that is significantly higher than that in the low-dose and the placebo groups. Such weight loss due to the intake of IQP-AE-103 is considered to be of clinical relevance as European Medicines Agency associates a weight loss of 5% or more with a decrease of disease risk factors associated with overweight and obesity [ 38]. Subgroup analysis showed that although both IQP-AE-103 high- and low-dose consumptions led to significant weight loss in overweight subjects, for moderately obese subjects, only high dose caused a significant body weight reduction. Subgroup analysis also showed a statistically significant weight loss in both high- and low-dose IQP-AE-103 groups in subjects aged 41–65 years when compared with placebo group, whereas only the high-dose group showed a significant weight loss versus placebo in subjects aged 18–40 years. C. Bachmann, “Ein Fasernkomplex zur Gewichtsreduktion und -kontrolle,” Current Therapeutic Research, vol. 76, pp. 25–27, 2010.View at: Google Scholar G. S. Hamilton and S. A. Joosten, “Obstructive sleep apnoea and obesity,” Australian Family Physician, vol. 46, no. 7, pp. 460–463, 2017.View at: Google Scholar Hunger Buddy is clinically proven to promote significant weight loss through a reduced food intake. It is particularly suitable for those who constantly have a big appetite and cannot control portion size. Hunger Buddy is a certified medical device product for the treatment and